期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1982
卷号：28
期号：5
页码：491-500
DOI：10.3177/jnsv.28.491
出版社：Center for Academic Publications Japan
摘要：Weanling rats (weaned 12 days after birth) were fed on nicotinic acid-deficient and on nicotinic acid-supplemented diet separately for 7 and 21 days. The yield of myelin in the brain of rat fed on the nicotinic acid-deficient diet was lower than that in the case of receipt of the nicotinic acid-supplemented diet at 19, 26 and 33 days of age. Despite the changing yield of myelin, the proportion of protein and total lipids, and the percentage composition of lipid were not changed between the groups fed on the nicotinic acid-deficient and the nicotinic acid-supplemented diet. Moreover, the ratio of long chain fatty acid (C20_23/C14_18) was markedly decreased in the nicotinic acid-deficient rats. These findings imply that nicotinic acid may play an important role in myelination associated with the synthesis of cerebrosides which contain high levels of long chain fatty acid.
关键词：nicotinic acid deficiency;myelin composition;fatty acid composition in myelin;cerebroside
