期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1982
卷号：28
期号：4
页码：343-350
DOI：10.3177/jnsv.28.343
出版社：Center for Academic Publications Japan
摘要：The effect of the feeding of a vitamin A-free diet on vitamin A metabolism was studied in rats by following changes in tissue distribution of the vitamin for 24 days. The serum level of vitamin A was maintained at a constant level until the last day of the experiment, by which time the liver reserve had declined to as low as one-seventh of its initial value. In contrast, the concentration of vitamin A in the kidney increased gradually in rats fed on a vitamin A-free diet and rose to levels higher than those in the liver after 24 days, whereas the kidney vitamin A concentration in the control animals remained at a constant level. In the testis, total vitamin A content increased in both the control group and that fed on a vitamin A-free diet. However, the magnitude of increase was smaller in the latter than in the former. Replenishment of the vitamin-A depleted rats with the vitamin provoked a prompt restoration of all changes produced by feeding of the depleted diet. Possible roles of the kidney are discussed with respect to homeostatic maintenance of the vitamin in vitamin A-depleted animals.
关键词：vitamin A-depletion;vitamin A-free diet;tissue vitamin A
