期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1974
卷号：20
期号：1
页码：1-7
DOI：10.3177/jnsv.20.1
出版社：Center for Academic Publications Japan
摘要：Biotin has been shown to have no significant influence on the total levels of folates in Escherichia coil . Exogenous biotin caused a redistribution of folate derivatives favouring the intracellular accumulation of unconjugated methyltetrahydrofolates at the expense of conjugated formyltetrahydrofolates. The decreased levels of the conjugated folates in presence of biotin has been attributed to the observed lowering in the levels of folylconjugate synthetase. The availability of intracellular glutamic acid was not a limiting factor in the presence of biotin. The observed lowering in the concentration of intracellular methionine in the biotin grown cells has been discussed in the light of the decreased levels of conjugated folates in these cells.
