期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1974
卷号：20
期号：1
页码：27-33
DOI：10.3177/jnsv.20.27
出版社：Center for Academic Publications Japan
摘要：To clarify the effect of thiamine on serotonin-related metabolism in magnesium-deficient rats, in vivo and in vitro experiments were carried out. In thiamine-excess magnesium-deficient and thiamine-adequate magnesium-deficient rats, serotonin oxidation activity in liver and stomach decreased significantly, while a decrease was not observed in thiamine-deficient magnesium-deficient rats. In vitro addition of a metal chelating agent and either thiamine or thiamine pyrophosphate to brain and liver mitochondria of intact rats resulted in a decrease in serotonin oxidation activities. Thus it is assumed that excess thiamine coupled with magnesium deficiency plays a role in the inhibition of serotonin oxidation and consequently serotonin increase.
