期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1973
卷号：19
期号：5
页码：383-388
DOI：10.3177/jnsv.19.383
出版社：Center for Academic Publications Japan
摘要：Methylmalonic aciduria is a metabolic defect characterized by an ex-cessive excretion of methylmalonic acid in the urine. The present paper reports the results obtained on rats fed a vitamin B12-deficient diet to which were administered propionate or the amino acids L-valine, L-isoleucine, L-methionine, L-threonine. Detection of metabolites was carried out by gas chromatography. The results obtained showed that besides propionate only L-valine and L-isoleucine cause an increase in the daily excretion of methylmalonic acid, while L-methionine and L-threonine have no effect on the rat.
