期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2004
卷号：50
期号：1
页码：1-8
DOI：10.3177/jnsv.50.1
出版社：Center for Academic Publications Japan
摘要：We studied non-hospitalized 30-69 y-old Japanese subjects to ascertain the influences of a 677C-T methylene-tetrahydrofolate reductase (MTHFR) genotype, nutri-tional intake and lifestyle-related factors on plasma homocysteine (Hcys) and serum folate concentrations. Hcys was higher and serum folate was lower in males than in females ( p <0, 01). The Hcys concentration was higher in the VV group than in the AA and AV groups for both males and females. However, a relatively low serum folate concentration of 18±7 nmol/L was found in the entire male group as compared with 22±10 nmol/L in all females. In the female subjects, serum folate concentrations differed among MTHFR geno-types, being lowest in the VV group. In all male subjects, log folate intake per 1, 000 kcal was a significant positive predictor of log serum folate concentration ( p <0.01), while in females the log vitamin C intake per standard body weight was a significant positive variable ( p <0.001) predicting the log serum folate concentration. Smokers had significantly lower serum folate concentrations, regardless of dietary folate intake. High folate and vitamin C consumptions, appears to be beneficial to normal and heterozygous MTHF genotype sub-jects for maintaining serum folate concentrations. Even a 400μg daily intake of folate might be less than what is needed, especially for homozygous MTHFR subjects and smokers, to maintain an adequate serum folate concentration.
