期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2003
卷号：49
期号：4
页码：287-288
DOI：10.3177/jnsv.49.287
出版社：Center for Academic Publications Japan
摘要：Recent evidence indicates that longevity may be achieved when efficient defence mechanisms against oxidative stress, infections, neoplasia, and cardiovascular events are preserved. Centenarians represent an example of “successful aging, ” and the aim of this study was to evaluate serum levels of vitamins A and E, which represent two important nonenzymatic antioxidant defence systems, and their correlation in 16 healthy centenarians and two groups of control subjects. Centenarians showed normal values of retinol (450.9±240.3ng/mL) and α-tocopherol (9220.2±3410.9ng/mL). Moreover, a significant direct correlation between the two vitamins was observed in centenarians (Rho=0.715, p =0.0056), such as in younger control subjects (Rho=0.618, p =0.0168), but not in older control subjects. We assume that the preservation of normal values and the correlation between vitamin A and E concentrations protects centenarians against oxidative stress and contributes to their extreme longevity.
