期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1995
卷号：41
期号：4
页码：493-498
DOI：10.3177/jnsv.41.493
出版社：Center for Academic Publications Japan
摘要：Therapy with all- trans retinoic acid (ATRA) achieves complete remission in a high proportion of patients with acute promyelocytic leukemia (APL), but the efficacy is reported to relate to plasma ATRA level after oral administration. The pharmacokinetics of ATRA and 4-oxo all- trans retinoic acid (4-oxo ATRA), a metabolite of ATRA, were studied in four children with APL at the time of initial oral administra-tion. After administration of ATRA at a dose of 30 mg/m2, the peak plasma ATRA level was 20-741ng/ml and was reached at 60-120min. The patient with the lowest peak plasma level did not achieve complete remission and had a very high 4-oxo ATRA level compared to the patients with complete remission. These findings suggest that accelerated metabo-lism of ATRA plays a role in the failure of this agent in the patients without remission.
