期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1995
卷号：41
期号：3
页码：273-280
DOI：10.3177/jnsv.41.273
出版社：Center for Academic Publications Japan
摘要：To compare the peroxidative susceptibilities of phosphati-dylcholine (PC) and phosphatidylethanolamine (PE) in liposomes, multi-lamellar vesicles (MLVs) were prepared with equimolar L-α-dilinoleoyl PC (DLPC) and L-α-dilinoleoyl PE (DLPE), and with soya PC and soya PE having a uniform constituent fatty acids. The hydroperoxide forma-tion at 37°C in the presence of a water-soluble radical initiator was examined by chemiluminescence-high-performance liquid chromatogra-phy (CL-HPLC), and the effect of heterogeneous distribution of PC and PE on peroxidation was investigated. No difference was found between the hydroperoxidation of PC and PE in MLVs systems, except that soya PC was more susceptible to peroxidation than soya PE in the L-α-dipal-mitoyl PC (DPPC)-based liposomes. No correlation was found between the amount of phospholipids distributed in the external leaflet of MLVs and hydroperoxide formation. This result suggested that the unsaturation of constituent fatty acids in phospholipids is more important than the difference in the polar head group of phospholipids regarding their peroxidizabilities in liposomes.
