期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1995
卷号：41
期号：3
页码：341-347
DOI：10.3177/jnsv.41.341
出版社：Center for Academic Publications Japan
摘要：Feeding rats with a diet containing 0.25% clofibrate for 2 weeks elevated the hepatic NAD+ and total nicotinate levels significantly. Other peroxisome proliferators, such as 2-(4-chlorophenoxy)propionic acid and di(2-ethylhexyl)phthalate, had similar effects. When rats were fed the control diet without clofibrate for 1 week after 2 weeks of the clofibrate diet, the hepatic NAD+ level returned to the control value. Muscular NAD+ content was not affected by the peroxisome pro-liferators. The results were discussed in relation to induction of peroxi-somal β-oxidation enzymes by the peroxisome proliferators.
关键词：rat;clofibrate;peroxisome proliferators;hepatic NAD+ content;hepatic total nicotinate content;muscular NAD+ content
