期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1994
卷号：40
期号：3
页码：283-288
DOI：10.3177/jnsv.40.283
出版社：Center for Academic Publications Japan
摘要：The relative proportions (% of total fatty acids) of odd-chain (15:0-29:0) and long-chain (22:0-30:0) saturated fatty acids in phospholipids of biotin-deficient rat lymphocytes were significantly in-creased as compared with biotin-supplemented rats, and the ratio of unsaturated fatty acids to saturated fatty acids in the former was signifi-cantly decreased mainly due to the reduced composition of poly-unsaturated fatty acids in the ω-3, ω-6, and ω-9 pathway. The ratio of cis-vaccenic acid to palmitoleic acid in biotin-deficient rats was signifi-cantly lower than that in control rats, and was thought to be another important, but previously unreported indicator of biotin deficiency. These changes imply that the elongation and desaturation of unsaturated fatty acids are depressed in lymphocytes of biotin-deficient rats, and may contribute to the associated immunological dysfunction in biotin deficien-cy through abnormal prostaglandin metabolism and/or cell membrane functions.
