期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1990
卷号：36
期号：2
页码：117-122
DOI：10.3177/jnsv.36.117
出版社：Center for Academic Publications Japan
摘要：Hypercholesterolemia due to feeding of polychlorinated biphenyls (PCB) and due to feeding of high cholesterol was compared. Rats in control group were fed a 25% casein diet, and those in PCB group or cholesterol group were fed the 25% casein diet supplemented with 0.03% PCB or 1% cholesterol and 0.25% cholic acid, respectively. Lipo-protein mass ( d <1.21g/ml) was higher 1.9- and 1.3-fold in rats fed PCB and cholesterol, respectively, as compared with controls. In rats fed PCB, protein, cholesterol, and phospholipid in the lipoprotein fraction markedly increased. Cholesterol-feeding resulted in the increase in pre-β-lipoprotein cholesterol, while PCB-feeding increased α-lipoprotein cholesterol and slightly slow migrated pre-β-lipoprotein cholesterol. PCB-treated rats had more apolipoprotein A-I in the lipoprotein fraction than control and cholesterol-fed rats. The data demonstrated that hyperlipoproteinemia induced by PCB is a novel α-lipoproteinemia and a useful model for investigating metabolism of high density lipoprotein.
关键词：PCB;cholesterol;high density lipoprotein;apolipoprotein A-I
