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  • 标题:Changes in Glucose/Amino Acid/Calcium Uptake and Brush-Border Membrane-Associated Enzymes in Rat Small Intestine after the Administration of Embelin (Plant Benzoquinone), an Antifertility Agent
  • 本地全文:下载
  • 作者:Sushil GUPTA ; Shankar Nath SANYAL ; Usha KANWAR
  • 期刊名称:Journal of Nutritional Science and Vitaminology
  • 印刷版ISSN:0301-4800
  • 电子版ISSN:1881-7742
  • 出版年度:1990
  • 卷号:36
  • 期号:2
  • 页码:153-164
  • DOI:10.3177/jnsv.36.153
  • 出版社:Center for Academic Publications Japan
  • 摘要:Administration of Embelin, an experimental antifertility agent, to male rats (20mg/kg body wt/day, daily for 15 and 30 days), caused an elevation in the uptake of D-glucose, L-alanine, L-leucine, and calcium in the small intestinal segments. An increase was also noted in the intestinal brush border membrane (BBM)-associated enzymes, sucrase, lactase, maltase, alkaline phosphatase, and leucine aminopeptidase in both the intestinal homogenates and partially purified BBM preparations, particularly after 30-day administration of the drug. Embelin treatment also caused a significant increase in the microsomal glucose-6-phosphatase and the cytosolic enzyme, lactate dehydrogenase. In the Embelin-treated animals BBM-associated total lipids, phospholipids, cholesterol, triacyl-glycerol, unesterified fatty acids, ganglioside-sialic acids as well as the cholesterol/phospholipids molar ratio showed a considerable increase. All these changes in the Embelin-treated animals were restored back to the normal or near normal biochemical makeup when the drug therapy was withdrawn and the animals were allowed to recover for another 15 and 30 days, respectively.
  • 关键词:Embelin;antifertility compound;intestinal uptake;glucose;amino acids;calcium;brush border membrane;hydrolases;membrane lipids
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