期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1978
卷号：24
期号：3
页码：263-270
DOI：10.3177/jnsv.24.263
出版社：Center for Academic Publications Japan
摘要：The action of two types of ascorbate-related reductones on nucleic acids was investigated by comparison with that of ascorbic acid (AsA). Amino reductone (ScA) and thiol reductone (MHC) caused strandscissions in nucleic acids. This was confirmed by the fact that reductones lowered the viscosity of DNA solution and shifted the peaks of DNA and RNA to the low molecular side in centrifugal profile. Cue2+ strengthened their action as in the case of enediol reductones. The breaking activity of thiol reductone is relatively weak compared with those of amino and enediol reductones, The preferential degradation of apurinic acid was caused with amino and thiol reductones, suggesting that pyrimidine clusters in nucleic acids were susceptible to breakage.
