期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1973
卷号：19
期号：4
页码：333-338
DOI：10.3177/jnsv.19.333
出版社：Center for Academic Publications Japan
摘要：With a view to study the changes in collagen crosslinking in vitamin E deficiency, two groups of weanling albino rats were fed with control and vitamin E-deficient diets respectively for 16 weeks and the samples of skins and urine were analysed. The results showed compared to the controls, vitamin E-deficient group showed an elevation of labile col-lagen, a decrease in the aldehyde content of neutral salt soluble col-lagen, increased susceptibility of insoluble collagen to denaturants and pronase. There is an increase of a1 and a2 subunits and a decrease of β11 and β12 subunits while the urinary excretion of hydroxyproline is not altered. These results suggest an impairment of collagen cross-linking probably involving a reduction in the aldehydic crosslinking precursor of collagen. The changes observed do not seem to be due to increased catabolism.
