摘要：Real Dysfunction Indicators in Lead Exposed Workers: Kap-Yeol JUNG, et al. Department of Preventive Medicine and Industrial Medicine Research Institute, Dong-A University School of Medicine —This study was undertaken to find out which indicators were most valuable as markers of renal dysfunction related to lead exposure. We selected 75 male workers from the secondary lead smelter, plastic stabilizer and radiator manufacturing industries (the “exposed” group) and 64 male office workers (the “control” group). Blood lead, blood zinc protoporphyrin, urine lead, urine coproporphyrin, δ-aminolevulinic acid dehydratase activity, and urine δ-aminolevulinic acid were chosen as indicators of lead exposure. Blood urea nitrogen, serum creatinine, serum uric acid, urine N-acetyl-β-D-lucosaminidase, urine albumin, urine α1-microglobulin and urine β2-microglobulin were used as indicators of renal dysfunction. The urine α1-microglobulin level was significantly associated with the lead exposure level. Blood urea nitrogen, urine N-acetyl-β-D-glucosaminidase and urine al-microglobulin levels were highly correlated with indicators of lead exposure. Urine α1-microglobulin had the highest correlation with other indicators of renal function. Conclusively, blood urea nitrogen, urine N-acetyl-β-D-glucosaminidase and urine α1-microglobulin are useful indicators, but urine α1-microglobulin is the earliest and the most valuable indicator of renal dysfunction due to lead exposure.
