出版社：National Institute of Occupational Safety and Health
摘要：The effects of mono-, di-, and tributyltin, which are widely used in industry, on human platelet aggregation were studied in vitro. The results demonstrated that these organic butyltin compounds inhibit epinephrine-induced aggregation. The antiaggregating concentrations (IC50) of the butyltin compounds were 10 nM for tributyltin, 10 μM for dibutyltin and 500 μM for monobutyltin. However, none of these compounds affected the platelet aggregation induced by others stimuli (ADP, arachidonate, and collagen). On the other hand, all of the butyltin compounds inhibited the binding of |3H|-DHEC to human platelets, and di-and tributyltin significantly inhibited the incorporation of |14C|-epinephrine into gel-filtered platelets. These results indicate that organic butyltin compounds inhibitepinephrine-inducedaggregation by blocking the epinephrine bindingto human platelets.
