出版社：National Institute of Occupational Safety and Health
摘要：The neurochemical effects of trimethyltin (TMT) intoxication were correlated with electron microscopic observations. Rats were injected intraperitone-ally with 1.0 mg TMT/kg body weight daily for 8 days. The administration of TMT diminished total lipid levels in all the regions of the brain. Phospholipids remained unaffected. However, cholesterol concentration was decreased in cerebral hemisphere and brain stem. Also, C/P ratio showed decrement in these regions. Moreover, esterified fatty acids were remarkably depleted in various brain regions. Interestingly, ganglioside contents showed depletion in the cerebellum and brain stem. Sulfhydryl radicals showed decreased levels in the brain stem only. Lipid peroxidation and lipase activity were elevated in the different regions of the brain. Furthermore, electron microscopic studies revealed remarkable accumulation of electron dense pigment bodies corresponding to the control.
关键词：Trimethyltin;Lipid fractions;CERL profiles;Pleomorphic electron dense bodies;Lipofuscin;Lipid peroxidation;Lipase activity
