出版社：National Institute of Occupational Safety and Health
摘要：Respiration and oxidative phosphorylation in rat liver mitochondria were investigated by the oxygen electrode method, and the livers of rats administered with polychlorinated naphthalene at 500 and 1000 mg/kg of food for 90 days were examined. A high dose of polychlorinated naphthalene given by intraperitoneal injection resulted in a significant decrease in the respiratory control index, a significant decrease in ATP level, but no significant change in ADP/O ratio in the liver. Polychlorinated naphthalene was detected by gas chromatography/mass-spectrometry. In the mitochondrial fraction, the shortest retention time component was detected at one hour after the injection. Mitochondria from rats receiving 500 mg/kg of food showed no significant change in the respiratory control index or ADP/O ratio, but a significant decrease in ATP level and an increase in triglyceride levels were observed. Rats fed on the food containing polychlorinated naphthalene at 1000 mg/kg showed significant changes in the respiratory control index and ADP/O ratio of the liver mitochondria, a significant decrease in ATP level and an increase in triglyceride levels.
