标题：EFFECTS OF CHLORINATED ALIPHATIC HYDROCARBONS ON MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION IN THE RAT WITH REFERENCE TO THE EFFECTS OF CHLORINATED AROMATIC HYDROCARBONS
出版社：National Institute of Occupational Safety and Health
摘要：The effects of chlorinated aliphatic hydrocarbons on mitochondrial energy transfer reactions in the rat were examined. Of the chlorinated aliphatic hydrocarbons examined, tetrachlorinated ones inhibited the respiratory control more strongly than trichlorinated ones with increasing state 4 respiration. The effect of chlorinated aliphatic hydrocarbons on the respiratory ccntrol was in the order of tetrachloroethylene > 1, 1, 1, 2-tetrachloroethane > trichloroethylene > 1, 1, 1-trichloro-ethane. These results indicate that chlorinated aliphatic hydrocarbons act as un-couplers of mitochondrial oxidative phosphorylation. The difference between the effects of chlorinated aliphatic and chlorinated aromatic hydrocarbons on the energy transfer reactions of rat liver mitochondria is discussed.
关键词：Chlorinated aliphatic hydrocarbons-Oxdative phosphorylation-Mitochon-drial-Respiratory control index-Chlorinated aromatic hydrocarbon
