出版社：National Institute of Occupational Safety and Health
摘要：The effects of chlorinated mono aromatic hydrocarbons on mitochondrial oxidative phosphorylation in rats were investigated. Of the chlorinated mono aromatic hydrocarbons examined, the tetra-and trichlorinated compounds strongly inhibited respiratory control with increasing state 4 respiration and decreasing state 3 respiration. The effect of the chlorinated mono aromatic hydro-carbons on the respiratory control of mitochondria was in the order of tetra ?? tri> di> mono chlorinated mono aromatic hydrocarbons, and the effect of isomers of the dichlorinated compounds was in the order of o-> m-> p-dichlorinated hydrocarbons. Chlorinated mono aromatic hydrocarbons also induced K+ release from mitochondria in the same order as the inhibitory effect on respiratory control, suggesting its interaction with the mitochondrial membrane and induction of a change in permeability to ions. It is concluded that chlorinated mono aromatic hydrocarbons act primarily as an uncoupler of the mitochondrial oxidative phosphorylation rather than as an electron transport or an energy transfer inhibitor. The destructive effect of the chlorinated mono aromatic hydrocarbons on the mitochondrial membrane was also demonstrated by the K+ release.
