出版社：National Institute of Occupational Safety and Health
摘要：Donryu, Wistar and Sprague-Dawley strains of rat were studied on their responses to the subcutaneously administered benzene at dose levels of 0, 0.2, 0.5 and 1.0 ml/ kg/day for 5 days. Criteria were body weight, hemoglobin, eryth rocyte, leucocyte, thrombocyte, thymus weight, and spleen weight. Among 3 strains of rat, Sprugue-Dawley was found most sensitive to benzene and to respond at a 0.5 ml/kg dose level. Female showed higher susceptibility to benzene than male. Useful criteria for benzene intoxication in rat might be the decrease of body weight, leucocyte count, thymus weight and spleen weight, and the increase of thrombocyte count. The Sprague-Dawley rat is found to be the best animal strain in the benzene intoxication experiment because of having many critical organs, the high-est suseptibility to benzene, and the smallest variation of the measurement. And the standardization of benzene poisoning experiment was shown from the viewpoint of animal species, dose and critical organs in relation to minimum effectivedose.
