出版社：National Institute of Occupational Safety and Health
摘要：Five strains of mice (ICR, ddN, CF#1, CFW and C3H) were divided into 4 groups respectively, which received benzene subcutaneously on the back at doses of 0, 0.2, 0.5 or 1.0 ml/kg for 5 days. On the sixth day of the experiment, body weight, hemoglo-bin, erythrocyte, leucocyte, thrombocyte, thymus weight and spleen weight were measur-ed to evaluate benzene intoxication. 1. Among five strains, ddN was the most susceptible and ICR was the least susceptible to benzene. 2. Male mice were found more susceptible to benzene than female in most strains of mice. 3. Useful criteria for benzene intoxication in mice might be leucocyte count, thymus weight and spleen weight. 4. ICR and ddN might be good strains for the experiment of benzene poisoning because of small coefficients of variance.
