标题：THE INHIBITORY EFFECT OF METHANOL ON FORSKOLIN-ACTIVATED ADENYLATE CYCLASE IN RAT ERYTHROCYTE MEMBRANES DEPENDENT ON THE STATE OF THE GUANINE NUCLEOTIDE-BINDING STIMULATORY AND REGULATORY PROTEIN
摘要：Forskolin-activated adenylate cyclase activity in rat erythrocyte membranes was markedly inhibited by methanol in a concentration dependent manner. On the contrary, no change was observed in the basal cyclase activity in the presence of methanol. The methanol inhibition forskolin-activated cyclase activity was protected by the stimulation of Gs in the presence of NaF in a concentration dependent manner. These data indicate that low-and high-affinity binding sites of forskolin in rat erythrocyte membranes have different sensitivities to methanol.
