摘要：Development of cross reverse tolerance between D-amphetamine, cocaine and morphine to their ambulation accelerating- and swimming time prolonging-effects was investigated in mice. D-Amphetamine and cocaine pretreatment did not increase the ambulation or swimming time by morphine, and pretreatment with morphine produced an increase in the response to D-amphetamine and cocaine. Thus, the difference of the underlying mechanisms between morphine and other drugs for the development of reverse tolerance to their ambulation accelerating and swimming time prolonging effects was demonstrated.
