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  • 标题:INHIBITION BY PROPRANOLOL OF HIGH POTASSIUM-INDUCED CONTRACTIONS IN THE RAT VAS DEFERENS
  • 本地全文:下载
  • 作者:NAGAO SUZUKI ; OSAMU INAGAKI ; CHIHIRO TAKAYAMA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1982
  • 卷号:5
  • 期号:11
  • 页码:936-940
  • DOI:10.1248/bpb1978.5.936
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:High concentrations of propranolol (10-5-3×10-4M) inhibited in a dosedependent fashion and reversibly the maximal contractile responses produced by 150 mM K+ in the rat vas deferens. 10-4M propranolol and quinine produced similar inhibitory effects on the dose-response curves to K+. Since norepinephrine-induced contractions were not substantially inhibited by quinine or propranolol, it was suggested that the two drugs may specifically inhibit the potassium-induced inflow of external calcium.
  • 关键词:rat vas deferens
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