标题：Isolation and Identification of the New Metabolites of 1-[Bis (4-fluorophenyl)-methyl]-4-(2, 3, 4-trimethoxybenzyl) piperazine Dihydrochloride (KB-2796) from Rat Bile, Urine and Feces
摘要：The metabolites of 1-[bis (4-fluorophenyl) methyl]-4-(2, 3, 4-trimethoxybenzyl) piperazine dihydrochloride (KB-2796) in the bile, urine and feces in rats were investigated after oral administration of [methine-14C], [benzyl-14C] and unlabelled KB-2796. Their structures were characterized by thin-layer chromatography, mass spectrometry, proton nuclear magnetic resonance and comparison with synthesized authentic compounds. The main pathways of biotransformation of KB-2796 in rats were : (a) O-demethylation at each methoxy group of the trimethoxybenzyl moiety, (b) N-dealkylation at 1 and 4-position of the piperazine ring and (c) hydroxylation at 5-position of the 2, 3, 4-trimethoxyphenyl ring.
