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  • 标题:Studies on Metabolic Pathways of Cyanate in Rats
  • 本地全文:下载
  • 作者:Ichiro KOSHIISHI ; Rie SHIBAYAMA ; Yasuko MORIMOTO
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1988
  • 卷号:11
  • 期号:11
  • 页码:730-735
  • DOI:10.1248/bpb1978.11.730
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Metabolic pathways of cyanate in rats were studied by means of measurements of cyanate, carbamyl phosphate and S-carbamyl group. Approximately 30-50% of cyanate administered to rats (0.5 mmol/kg body weight) was found in buffered gastric contents, and was also detected as ammonia liberated by acid hydrolysis. However, the gastric excretion of cyanate was a temporary phenomenon just after cyanate administration. Biliary and urinary excretion of cyanate and acid-soluble S-carbamyl group are minor metabolic pathways.
  • 关键词:uremic toxin
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