标题：PHARMACOLOGICAL STUDIES ON THE RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS DURING ANTI-IMMUNOGLOBULIN E ANTIBODY MEDIATED PASSIVE PERITONEAL ANAPHYLAXIS IN RATS
摘要：The release of slow reacting substance of anaphylaxis (SRS-A) by antiimmunoglobulin E (IgE ; ∈)-antibody mediated passive peritoneal anaphylaxis (PPA) in rats was investigated immunopharmacologically. 1) A significant amount of SRS-A was released by anti-∈-antibody in the peritoneal cavity of rats passively sensitized with IgE. The amount of SRS-A released by anti-∈-antibody was about one third less than that released in an anti-γ-antibody and IgG2a system. 2) The release of SRS-A was initiated at 2 min and reached its maximum 5 to 10 min after the injection of anti-∈-antibody. 3) Disodium cromoglycate, tranilast and ketotifen inhibited the release of both SRS-A and histamine caused by anti-∈-antibody mediated PPA. 4) Glucocorticoids (hydrocortisone, prednisolone and dexamethasone) also inhibited the release of both mediators. 5) p-Bromophenacyl bromide inhibited the release of both mediators. AA-861, a potent 5-lipoxygenase inhibitor, inhibited the release of SRS-A but not histamine. 6) Indomethacin slightly enhanced the release of SRS-A and inhibited the release of histamine. 7) Cytarabine resulted in leucopenia and inhibited the release of histamine but not SRS-A during PPA. 8) Dextran sulfate reduced the number of glass adherent peritoneal cells and inhibited the release of SRS-A but not histamine. These results suggest the suitability of anti-∈-antibody mediated rat PPA for investigating the effect of anti-allergic agents on the release of SRS-A.
