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  • 标题:EFFECTS OF PROPRANOLOL ON TISSUE NECROSIS IN EXPERIMENTAL MYOCARDIAL INFARCTION IN DOGS
  • 本地全文:下载
  • 作者:KATSUHARU TSUCHIDA ; RYUZABURO YAMAZAKI ; KATSUYOSHI KANEKO
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1986
  • 卷号:9
  • 期号:10
  • 页码:836-841
  • DOI:10.1248/bpb1978.9.836
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:We studied the effects of propranolol on degradation of cardiac structural proteins resulting from ischemia induced by 24 h ligation of the coronary artery in dogs. Degradation of myocardial myosin heavy chain, α-actinin and troponin-I was used as an indicator of degradation of cardiac structural proteins. In dogs with left circumflex coronary artery ligation, propranolol, given orally in the dose of 10 or 30 mg/kg, significantly reduced degradation of cardiac structural proteins. This can be supported by the facts that treatment with propranolol, 10 or 30 mg/kg, reduced release of cathepsins B, L and D from lysosome to cytosol in the ischemic tissue and that the reduced acidity of the ischemic tissue was improved by treatment with propranolol, 30 mg/kg. In conclusion, propranlol delays the necrotic development of the severely ischemic myocardial tissue as shown by reduced protein degradation.
  • 关键词:propranolol
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