标题：STRUCTURE-ACTIVITY RELATIONSHIP OF CARDIAC STEROIDS HAVING A DOUBLY LINKED SUGAR AND RELATED COMPOUNDS FOR THE INHIBITION OF Na+, K+-ADENOSINE TRIPHOSPHATASE
摘要：Forty-three different cardiac steroids having a doubly linked sugar and related compounds were tested for inhibition of Na+, K+-adenosine triphosphatase from guinea pig heart, and the structure-activity relationship has been discussed. The doubly linked glycosides showed higher activities than the respective genins. The inhibitory activities of these compounds were also dependent upon the presence of ring C substituents. The bufadienolide rhamnosides exhibited greater than three times the inhibitory activity of the parent genin, while the glucosyl residue exerted no significant activity.
