摘要：The anti-inflammatory activity of a proteinase inhibitor on carrageenin-induced inflammation was studied by using N-(2, 4-dinitrophenyl)-benzisothiazolinone-1, 1-dioxide, a selective inhibitor of elastase, cathepsin G and chymotrypsin. The selective inhibitor suppressed leukocyte chemotaxis in vivo and in vitro, vascular permeability and development of granulation tissue. These results suggest that a selective inhibitor of elastase, cathepsin G and chymotrypsin is an effective agent for suppression of induction and development of carrageenin-induced inflammation in rats.
