摘要：The experiments were conducted in order to examine the mechanism of hyperthermia induced by l-ephedrine in rats. β-Adrenoceptor agonists have been known to enhance normal body temperature. Therefore, the effect of various β-adrenoceptor agonists on body temperature in rats was examined to clarify the mechanism of action of l-ephedrine. The results showed that drugs with β2-adrenoceptor agonist activity and l-ephedrine caused hyperthermia in rats and this effect was selectively inhibited by pretreatment of animals with propranolol (a mixed β-adrenoceptor antagonist) or butoxamine (a selective β2-adrenoceptor antagonist). These results suggest that hyperthermic action of l-ephedrine may largely be due to its effect on β2-adrenoceptors.
