摘要：Estradiol 17-sulfate 2-hydroxylase activity was measured in liver microsomes of 7-to 8-weeks-old Wistar male rats. Phenobarbital (80 mg/kg, daily for 4 d) injected intraperitoneally caused 30% increase of the enzyme activity and 160% increase of the microsomal cytochrome P-450 content. Treatment of rats with 3-methylcholanthrene (40 mg/kg, daily for 4 d) injected intraperitoneally caused no induction effect on 2-hydroxylase activity, but P-450 content was increased by 113%. Both the P-450 content and the enzyme activity were reduced to about half of the control, when the animals were injected subcutaneously with cobaltous chloride (30 mg/kg, daily for 2 d).
