标题：YM-14673, a New Thyrotropin-Releasing Hormone Analog, Augments Long-Term Potentiation in the Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
摘要：Effects of a new thyrotropin-releasing hormone (TRH) analog, Nα-[[(S)-4-oxo-2-azetidinyl] carbonyl] L-histidyl-L-prolinamide dihydrate (YM-14673), which improves experimentally induced memory dysfunction, on long-term potentiation (LTP) in the mossy fiber-CA3 system, were investigated using guinea pig hippocampal slices. At concentrations of 10-7 M and 10-6M, YM-14673 significantly augmented LTP in a concentration dependent manner. The magnitude of effect of 10-6M YM-14673 was similar to that of 10-6M TRH. As LTP in the hippocampus is regarded as an elementary process of memory and learning, the augmenting effect of YM-14673 on LTP in the present study may contribute to this drug's ability to remedy memory dysfunction.
