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  • 标题:DEVELOPMENT AND EVALUATION OF A NEW PERORAL TEST AGENT GA-TEST FOR ASSESSMENT OF GASTRIC ACIDITY
  • 本地全文:下载
  • 作者:HIROYASU OGATA ; NOBUO AOYAGI ; NAHOKO KANIWA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1984
  • 卷号:7
  • 期号:9
  • 页码:656-664
  • DOI:10.1248/bpb1978.7.656
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:A new peroral test capsule, GA-Test, containing riboflavin (5mg) granules coated with polyvinylacetal diethylaminoacetate (AEA【○!R】) for assessing gastric acidity without intubation was developed and evaluated for usefulness. GA-Test is based on the tracing in the urine of riboflavin, which is released in the stomach only in the presence of acidic fluid and is absorbed. Due to the film coating, riboflavin released very quickly at a pH of less than 5, and not at all at a pH of greater than 6. GA-Test gave a significant correlation, quantitatively, with peroral Gastrotest【○!R】 in assessing acidity, a non-intubation method which had been marketed in Japan prior to 1980. GA-Test results allowed division of the subjects into two groups i.e., subjects having low (hypo-or anacidity) gastric acidity and those having high (normal or hyperacidity) gastric acidity, GA-Test results agreed well with results of intubation (around 91.4% ; 32 out of 35 cases) and were easily reproduced during the evaluation.
  • 关键词:bioavailability test
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