摘要：Induction effect of phenobarbital (80mg/kg, daily for 4d), 3-methylcholanthrene (40mg/kg, daily for 4d), and isosafrole (150mg/kg, daily for 4d), on 2-and 4-hydroxylations of estradiol 17-sulfate by rat liver microsomes with an NADPH-generating system was investigated. On catechol formation from estradiol 17-sulfate, only phenobarbital caused some increase of the 2-hydroxylase activity in both sexes. While 4-hydroxylase activity was caused effectively by phenobarbital and isosafrole in both sexes, especially, the induction by the former in male rats was over six-fold increase to the control.
