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  • 标题:INTESTINAL ABSORPTION OF dl-α-TOCOPHEROL FROM BILE SALTS AND POLYSORBATE 80 MICELLAR SOLUTIONS IN RAT
  • 本地全文:下载
  • 作者:JUN IMAI ; MASAHIRO HAYASHI ; SHOJI AWAZU
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1983
  • 卷号:6
  • 期号:12
  • 页码:897-902
  • DOI:10.1248/bpb1978.6.897
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    The intestinal absorption of dl-α-tocopherol (VE) from various micellar solutions was studied by the in situ recirculating perfusion in rat small intestine. The perfused micellar solutions of VE were formed by sodium taurocholate (STC), sodium taurodeoxycholate (STDC) or polysorbate 80 (PS-80). The absorption ratio of VE was STC>STDC>PS-80 micellar solutions. The addition of egg lecithin (PC) to all micellar solutions caused the decrease of the absorption. The absorption ratio did not necessarily have a simple correlation with the VE solubilization in these micellar solutions. And it was also found that the absorption ratio correlated with the micellar size and with net water flux in the intestinal lumen.

  • 关键词:solvent drag
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