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  • 标题:THE INADEQUACY OF THE RANEY NICKEL DESULFURATION METHOD FOR THE STRUCTURAL ELUCIDATION OF AN EPOXIDE-GLUTATHIONE S-CONJUGATE : DESULFURATION OF PHENYLOXIRAN-GLUTATHIONE S-CONJUGATES TO PHENYLOXIRAN
  • 本地全文:下载
  • 作者:TADASHI WATABE ; AKIRA HIRATSUKA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1982
  • 卷号:5
  • 期号:9
  • 页码:653-658
  • DOI:10.1248/bpb1978.5.653
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Both of purely separated regioisomers of phenyloxiran-glutathione S-conjugates, conjugate 1 (S-(1-phenyl-2-hydroxyethyl)glutathione) and conjugate 2 (S-(2-phenyl-2-hydroxyethyl)glutathione), afforded phenyloxiran as a common intermediate to the major desulfuration products, phenethyl alcohol and ethylbenzene, and to the minor ones, methyl-phenylcarbinol and toluene, on the mild treatment with Raney nickel in boiling ethanol. Phenyloxiran formed was hydrogenated to stable phenethyl alcohol and unstable methylphenylcarbinol under the catalytic conditions used, the latter of which was readily deoxygenated to ethylbenzene. The present study indicated that the Raney nickel method, despite of its being recognized to be well established, could not be applicable to the structural assigment of epoxide-glutathione or epoxide-mercapturic acid conjugates.
  • 关键词:desulfuration
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