摘要：The urinary excretion of 2-hydroxypropyl methyl sulfone (2HPMS) and methyl propyl sulfone (MPS) after oral administration of thiamine propyl disulfide (TPD) was examined in the patients with various liver diseases, in order to investigate the relationship between the liver function and the ability of drug disposition including metabolism. The patients were divided into six groups as follows ; acute hepatitis in convalescent stage (AHconv), acute hepatitis in active stage (AHact), chronic inactive hepatitis (CIH), chronic active hepatitis (CAH), liver cirrhosis in compensated stage (LCcom) and decompensated stage (LCdec). The results obtained from these groups were compared with those of normal subjects. For MPS, only LCdec showed either lesser or delayed excretion in the 0-48 h urine compared to normal subjects. In other liver diseases the excretion pattern of MPS was similar with that of normal subjects, and the amount excreted in the 0-48 h urine was not significantly different. In urinary excretion of 2HPMS, the amount excreted in the 0-48 h urine decreased in the order CIH > AHconv > AHact > CAH > LCcom > LCdec, and the decrease in the amount correlated roughly to the severity of liver disease. This amount in liver disease, except CIH, was significantly less than that in normal subjects. Differences between CIH and CAH, and LCcom and LCdec were also significant. Delayed excretion of 2HPMS was observed in chronic liver diseases, especially in LCdec. Excretion of 2HPMS in the 0-48 h urine was correlated with the alterations of liver functions such as serum albumin concentration, serum choline esterase activity, hepaplastin test and indocyanine green tolerance test. From the results, measurement of the amount of 2HPMS excreted in the 0-48 h urine after oral dose of TPD is suggested to be useful for evaluation of the liver function.
