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  • 标题:A NOVEL METABOLITE OF OXYCODONE IN THE URINE OF RABBITS
  • 本地全文:下载
  • 作者:TAKASHI ISHIDA ; KAZUTA OGURI ; HIDETOSHI YOSHIMURA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1982
  • 卷号:5
  • 期号:2
  • 页码:134-136
  • DOI:10.1248/bpb1978.5.134
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:In addition to six metabolites of oxycodone which were reported previously, 7β-hydroxy-6β-oxycodol was further isolated as one of the major metabolites in rabbits. The structure of this novel metabolite was characterized by mass and nuclear magnetic resonance spectra. Such a metabolite possessing vicinal hydroxyl groups in aliphatic ring is very new in the metabolism of narcotic analgesics.
  • 关键词:nuclear magnetic resonance spectrum
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