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  • 标题:ONTOGENESIS OF REARING AND STEREOTYPY RESPONSES TO APOMORPHINE IN THE RAT
  • 本地全文:下载
  • 作者:YASUYUKI NOMURA ; TOMIO SEGAWA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1980
  • 卷号:3
  • 期号:2
  • 页码:69-73
  • DOI:10.1248/bpb1978.3.69
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The ontogenesis of rearing and stereotypy behavior in response to apomorphine were investigated in the developing rat. The rearing was rarely observed in 15-day-old rats but distinctly in 18-day-old ones. A subcutaneous injection of apomorphine in dose of 1 mg/kg or 2 mg/kg decreased the frequency of rearing in older animals than day 20. On the other hand, 15-day-old rats were already responsive to apomorphine in stereotypy behavior. There was a reciprocal relationship between rearing and stereotypy responses to apomorphine in rat older than 18 days. Functional relationship between rearing and stereotypy in response to apomorphine were discussed in view of the central dopaminergic mechanisms in developing rats.
  • 关键词:dopaminergic mechanism
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