摘要：Recent findings that di (2-ethylhexyl) phthalate (DEHP) caused reproductive toxicity and carcinogenicity in animals have again raised a concern over the human health implications of the widespread use of phthalate esters (PAEs) as plasticizers in poly vinyl chloride (PVC) products. Topics included in this review are 1) environmental toxicological aspects, 2) comparative metabolisms and pharmacokinetics, 3) feto/embryo toxicity and teratogenicity, 4) gonad toxicity to produce testicular atrophy, 5) genotoxic potency ; mutagenic and other genotoxic effects, 6) hepatocarcinogenicity which may be associated with peroxisome proliferation and tumor promoting activity. The results of our toxicological study on PAEs are also included.
