摘要：^<14>C (U)-carbazole was orally administrated to female rats, and the distribution of 14C in organs and tissues and the excretion were examined. The mutagenicity of carbazole was tested by spore rec-assay with B. subtilis and by Ames test with S. typhimurium TA 100 and TA 98. In 24h, 70% of 14C-carbazole was excreted in the urine and the rest (33%) in the feces. Most of the metabolite of carbazole was conjugated and existed as hydroxy-carbazole. Intaked 14C was mainly distributed into blood, kidney and liver in the early stage. The same trend was shown until 24 h after the administration, although the concentration gradually decreased. From these results of distribution, Biological Half Life (BHL) was calculated as follows, liver (13.7 h), adrenal (12.4 h), thyroid (12 h) and brain (11.5 h). The 14C concentration in gastrointestinal tract decreased to less than 1% in 24 h and small discharge to bile was observed. The mutagenicity was not detected by rec-assay nor by Ames test.
