摘要：Methamphetamine and its metabolites in hair samples obtained from habitual user of methamphetamine were identified and determined by mass fragmentography (MF). Hair sample was washed with water and methanol. The hair was crushed in 0.6 N HCl, suspension was alkalized with Na2CO3, and extracted with chloroform-isopropanol (3 : 1, v/v). The extract obtained was trifluoroacetylated, and applied to MF. Methamphetamine was detected in all hair samples obtained from 9 habitual users, and its contents were 0.7 to 67.5 ng/mg hair. Amphetamine, which was known as a metabolite of methamphetamine, was also detected in 6 hair samples of 9. Methamphetamine could be detected in hair sample obtained from the 37 d drug-free abuser. It is considered that analysis of methamphetamine in hair samples by MF is one of useful methods for discrimination of habitual user of methamphetamine. Furthermore, distribution of methamphetamine to top, middle and root parts of hair was examined. The results suggest that the distribution of mathamphetamine in a hair may be correlated with the individual history of abuse of drug.
