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  • 标题:Toxicologic Investigation of Dimethylacrylamide in Mice
  • 本地全文:下载
  • 作者:EIICHI HAYASHI ; MASARU KUNITOMO ; MAMORU TERADA
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1974
  • 卷号:20
  • 期号:6
  • 页码:317-321
  • DOI:10.1248/jhs1956.20.317
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Acute and subacute toxicity of dimethylacrylamide in mice was studied. LD50 by a single oral dose was 485 mg/kg (male) and 460 mg/kg (female), and that by subcutaneous injection was 580 mg/kg (male) and 590 mg/kg (female). In a subacute toxicity test for a 6-week period, no adverse change attributable to the ingestion of dimethylacrylamide was observed in body weight, gross physiological appearance, and in clinical, histopathological, and hematological examinations, except a slight increase in the weight of the liver, spleen, and testis.
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