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  • 标题:鉛中毒ラットのポルフィリン代謝について自動車排気成分による複合的影響
  • 本地全文:下载
  • 作者:山本 丈夫 ; 山口 正義 ; 祐田 泰延
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:1974
  • 卷号:20
  • 期号:5
  • 页码:261-265
  • DOI:10.1248/jhs1956.20.261
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:In at least some urban areas, population exposure to elevated lead levels in the atmosphere with high motallization is associated with increased blood level of lead. Lead is known to interfere in porphyrin metabolism and the effect of motor vehicle pollution on porphyrin metabolism in lead poisoning was examined with lead-intoxicated rats with the following results : 1) Urinary excretion of coproporphyrin and δ-aminolevulinic acid was significantly higher in leadpretreated rats by their exposure to motor vehicle pollutants in a traffic lane. 2) By exposure to motor vehicle pollutants in a traffic lane, urinary excretion of coproporphyrin in lead-pretreated rats became higher than that of δ-aminolevulinic acid.
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