摘要：Fourteen kinds of commercial cosmetic azo-dyes and their authentic compounds which were synthesized and purified were tested for their mutagenic activities in Ames test. Total number of commercial samples tested was 65. Orange 203 was mutagenic to S. typhimurium TA98 and TA100 without S9 mix. and Red 228 was highly mutagenic after it was treated with S9 mix. Red 201, 202, 219 and 220 showed the weak mutagenic activities to S. typhimurium TA98 which would be due to impurities contained in these azo-dyes. Red 203, 204, 207, 221, 505, Orange 205, 403 and Yellow 401 showed no mutagenic activities to both strains of bacteria with or without S9 mix.
关键词：mutagenicity;Ames test;S. typhimurium TA98 and TA100;cosmetic azo-dye;impurity
