摘要：The protein and deoxyribonucleic acid (DNA) concentrations, and acid deoxyribonulease activity of femur were examined in rats intraperitoneally administered cadmium acetate, lead acetate, zinc acetate, or combined metals (0.89 μmol as a metal ion/100g body weight) 5 times at 2-day intervals. The bone protein concentration after the injection of cadmium, zinc, and combined metals significantly decreased in the diaphysis of femur compared with that of normal rats, but the protein concentration in the epiphysis was significantly increased by zinc alone. The DNA concentration in the epiphysis significantly increased by the administration of any of the metals, while it was significantly increased in the diaphysis by zinc alone. On the other hand, the acid deoxyribonuclease activity in the diaphysis was not altered significantly by any of the metals, but this enzyme activity was significantly reduced in the epiphysis by zinc alone. The present results suggest that the effect of zinc on bone metabolism differs from that of cadmium and lead.
