摘要：Colorimetric determination of pheneacetin and Bucetin in mixed pharmaceutical preparations was examined. Phenacetin and Bucetin react with nitric acid-acetic acid -0.1% sodium nitrite (40 : 10 : 0.1) solution to give nitrophenacetin and nitrobucetin, respectivly. Nitrophenacetin and nitrobucetin were each hydrolyzed with sodium hydroxide to produce nitrophenetidine which was extracted with chloroform and showed absorption maximum at 435 nm. Presence of acetaminophen, salicylamide, and potassium guaiacolsulfonate does not interfere with this method.
